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Furosemide was devoid of mutagenic activity in various strains of Salmonella typhimurium when tested in the presence or absence of an in vitro metabolic activation systemand questionably positive for gene mutation in mouse lymphoma cells in the presence of rat liver S9 at the highest dose testedFurosemide did not induce sister chromatid exchange in human cells in vitrobut other studies on chromosomal aberrations in human cells in vitro gave conflicting resultsIn Chinese hamster cells it induced chromosomal damage but was questionably positive for sister chromatid exchangeStudies on the induction by furosemide of chromosomal aberrations in mice were inconclusiveThe urine of rats treated with this drug did not induce gene conversion in Saccharomyces cerevisiae
Signs of an electrolyte imbalancedry mouthincreased thirstmood changesweaknessdrowsinesslack of energymuscle painfast heartbeatsfeeling restlessnauseavomiting.
In chronic kidney diseases with hypoalbuminemiait is used along with albumin to increase diuresisIt is also used along with albumin in nephrotic syndrome to reduce edema.
Applies to furosemidecompounding powderinjectable solutionintravenous solutionoral liquidoral solutionoral tablet.
Reversible elevations of BUN may occur and are associated with dehydrationwhich should be avoidedparticularly in patients with renal insufficiency.
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