The safety and efficacy of ditropan xl chloride was evaluated in a total of 199 patients in three clinical trials.
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Overdosage with oxybutynin chloride has been associated with anticholinergic effects including central nervous system excitatione.grestlessnesstremorirritabilityconvulsionsdeliriumhallucinationsflushingfeverdehydrationcardiac arrhythmiavomitingand urinary retentionOther symptoms may include hypotension or hypertensionrespiratory failureparalysisand coma.
DITROPAN is also contraindicated in patients who have demonstrated hypersensitivity to the drug substance or other components of the product.
Oxybutynin chloride exerts a direct antispasmodic effect on smooth muscle and inhibits the muscarinic action of acetylcholine on smooth muscleOxybutynin chloride exhibits only one fifth of the anticholinergic activity of atropine on the rabbit detrusor musclebut four to ten times the antispasmodic activityNo blocking effects occur at skeletal neuromuscular junctions or autonomic gangliaantinicotinic effects
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