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Drugs that decrease the serum digoxin concentration by decreasing absorption .

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Information about Digoxin.

Do not switch between different PO forms or between brand and generic forms of digoxinbioavailability varies.

If you are taking digoxin and you have any concernsor any new or worsening symptomsdo not stop taking your medicationbut contact your health professional as soon as possible.

To make sure you can safely take digoxintell your doctor if you have any of these other conditions:

Get emergency medical help if you have signs of an allergic reaction to digoxinhivesdifficulty breathingswelling of your facelipstongueor throat.

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be careful with moduretic if you take potassium-sparing diuretics eg, spironolactone , potassium supplements, or salt substitutes containing potassium because high blood potassium levels may occur and cause listlessness, confusion, abnormal skin sensations of the arms and legs, heaviness of limbs, slowed heart rate, irregular heart rhythm, or stopping of the heart; cholestyramine or colestipol because they may decrease moduretic s effectiveness; nonsteroidal anti-inflammatory drugs nsaids eg, indomethacin because they may decrease moduretic s effectiveness and risk of kidney problems may be increased; barbiturates eg, phenobarbital , certain chemotherapy medicines, corticosteroids eg, prednisone , digoxin, dofetilide, ketanserin, narcotic pain medicines eg, codeine , or medicines for high blood pressure because the risk of their side effects may be increased by moduretic; diazoxide, lithium, or nondepolarizing neuromuscular blockers eg, pancuronium because their actions and the risk of their side effects may be increased by moduretic; angiotensin-converting enzyme ace inhibitors eg, enalapril because the risk of high blood potassium and kidney problems may be increased by moduretic; diabetes medicines eg, glipizide or insulin because their effectiveness may be decreased by moduretic.

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