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No information is available on interactions between Nicotinell TTS and other drugsNo clinically relevant interactions between nicotine replacement therapy and other drugs has definitely been establishedhowever nicotine may possibly enhance the haemodynamic effects of adenosine.

Polycyclic aromatic hydrocarbons in tobacco smoke induce the metabolism of drugs catalysed by CYP 1A2and possibly by CYP 1A1When a smoker stopsthis may result in slower metabolism and a consequent rise in blood levels of such drugs.

In principlethe Nicotinell TTS can cause adverse reactions similar to those associated with nicotine administered by other meansincluding smokingand these are mainly dose dependentSince the maximum plasma concentrations of nicotine that are produced by the patch are lower than those produced by smoking and fluctuate lessnicotine-related adverse reactions occurring during treatment with the patch can be expected to be less marked than during smoking.

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nicotinell gum comes in mint, fruit and liquourice flavours.

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