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Numerous antihypertensive drugsfrom a variety of pharmacologic classes and with different mechanisms of actionhave been shown in randomized controlled trials to reduce cardiovascular morbidity and mortalityand it can be concluded that it is blood pressure reductionand not some other pharmacologic property of the drugsthat is largely responsible for those benefitsThe largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of strokebut reductions in myocardial infarction and cardiovascular mortality also have been seen regularly.
The precise mechanisms by which amlodipine relieves angina have not been fully delineatedbut are thought to include the following:
In rare caseswhen you first start taking Norvascyour angina may get worse or you could have a heart attackSeek emergency medical attention or call your doctor right away if you have symptoms such aschest pain or pressurepain spreading to your jaw or shouldernauseasweating.
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