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Following oral administration of lisinopril, peak serum concentrations occur within about 7 hours.

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Weak arms and legs or problems speakingthese can be signs of a stroke yellow skin or eyesthis can be a sign of liver problems palenessfeeling tiredfaint or dizzyany sign of bleedingfor example bleeding from the gums or bruising more easily than usualsore throat and fever and getting infections more easilythese can be signs of blood or bone marrow disorder a faster heart ratechest pain and tightness in your chestthese can be signs of heart problems shortness of breathwheezing and tightening of the chestthese can be signs of lung problems severe tummy painthis can be a sign of an inflamed pancreas swollen anklesblood in your pee or not peeing at allthese can be signs of kidney problems.

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Your doctor may suggest that you take your first dose before bedtimebecause it can make you dizzyAfter the very first doseyou can take lisinopril at any time every dayTry to take it at the same time every day.

Frequency not reportedGouthypoglycemia in diabetic patients receiving ACE inhibitors when concurrently treated with oral antidiabetic agents or insulinRef]

US BOXED WARNINGS FETAL TOXICITYAngiotensin converting enzymeACEinhibitor use during pregnancy can cause morbidity and death to the developing fetusWhen used during the second and third trimestersACE inhibitors have been associated with fetal and neonatal injuryincluding hypotensionneonatal skull hypoplasiaanuriareversible or irreversible renal failureand deathOligohydramnios has also been reportedpresumably resulting from decreased fetal renal functionoligohydramnios in this setting has been associated with fetal limb contracturescraniofacial deformationand hypoplastic lung developmentExposure to ACE inhibitors during the first trimester of pregnancy has been associated with prematurityintrauterine growth retardationpatent ductus arteriosusother structural cardiac malformationsand neurological malformationsWhen pregnancy is detectedACE inhibitors should be discontinued as soon as possibleIf no alternative to ACE inhibitor therapy is availablepatients should be made aware of the risks to their fetuses and the intra-amniotic environment should be evaluated by serial ultrasound examinationsIf oligohydramnios developsthis drug should be discontinued unless it is considered lifesaving for the motherDepending on the week of pregnancycontraction stress testinga nonstress testor biophysical profiling may be appropriateOligohydramnios may not show until after the fetus has suffered irreversible injury.

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like all medicines, lisinopril can cause side effects, although not everybody gets them.

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