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CRESTOR significantly increased INR in patients receiving coumarin anticoagulantsThereforecaution should be exercised when coumarin anticoagulants are given in conjunction with CRESTORIn patients taking coumarin anticoagulants and CRESTOR concomitantlyINR should be determined before starting CRESTOR and frequently enough during early therapy to ensure that no significant alteration of INR occurssee WARNINGS AND PRECAUTIONS and CLINICAL PHARMACOLOGY
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