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Isakson the half-life of celebrex is about 11 to 12 hours which means that it is expelled from the body within about 2 1 2 to 3 days after discontinuing the medicine.

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Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusionIn these patientsadministration of an NSAID may cause a dose-dependent reduction in prostaglandin formation andsecondarilyin renal blood flowwhich may precipitate overt renal decompensationPatients at greatest risk of this reaction are those with impaired renal functiondehydrationhypovolemiaheart failureliver dysfunctionthose taking diureticsACE-inhibitors or the ARBsand the elderlyDiscontinuation of NSAID therapy is usually followed by recovery to the pretreatment state.

The effects of celecoxib on the pharmacokinetics and/or pharmacodynamics of glyburideketoconazolesee DRUG INTERACTIONSphenytoinand tolbutamide have been studied in vivo and clinically important interactions have not been found.

If you take too much of your NSAIDcall your healthcare provider or get medical help right away.

Clinical trials of other COX-2 selective and non-selective NSAIDs of up to three-years duration have shown an increased risk of serious cardiovascular thrombotic eventsmyocardial infarctionand strokewhich can be fatalAs a resultall NSAIDs are considered potentially associated with this risk.

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