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In five multiple-dose studies in healthy subjects n 82 and in subjects with epilepsy n 86 , when administered under fasting and nonfasting conditions, depakote er given once daily produced an average bioavailability of 89 relative to an equal total daily dose of depakote given bid, tid, or qid.

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Get emergency medical help if you have signs of an allergic reaction to Depakotehivesdifficult breathingswelling in your face or throator a severe skin reactionfeversore throatburning eyesskin painred or purple skin rash with blistering and peeling

Please see the full Prescribing Informationincluding Medication Guidefor additional information about DepakoteTalk to your healthcare provider if you have questions.

Check with your doctor immediately if any of the following side effects occur while taking divalproex sodium:

Use effective birth control while using this medicineand tell your doctor right away if you become pregnantTell your doctor if you start or stop using hormonal contraception that contains estrogenbirth control pillsinjectionsimplantsskin patchesand vaginal ringsEstrogen can interact with this medicine and make it less effective in preventing seizures.

Depakotedivalproex sodiumaffects chemicals in the body that may be involved in causing seizures.

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