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Your doctor should do blood tests to check your liver before starting treatment and if you have symptoms of liver problems while taking CRESTOR Call your doctor right away if youHave unexplained muscle pain or weaknessespecially with fever Have muscle problems that do not go away even after your doctor told you to stop taking CRESTOR Feel unusually tired Have loss of appetiteupper belly paindark urineor yellowing of skin or eyesThese could be signs of rare but serious side effects Elevated blood sugar levels have been reported with statinsincluding CRESTOR Side effectsThe most common side effects may include headachemuscle achesabdominal painweaknessand nauseaMemory loss and confusion have also been reported with statinsincluding CRESTOR Tell your doctor and pharmacist about other medicines you are taking.

Cyclosporinea medicine for your immune systemgemfibrozila fibric acid medicine for lowering cholesterolantiviral medicines including HIV or hepatitis Cprotease inhibitorssuch as lopinavirritonavirfosamprenavirtipranaviratazanaviror simeprevircertain anti-fungal medicinessuch as itraconazoleketoconazole and fluconazolecoumarin anticoagulantsmedicines that prevent blood clotssuch as warfarinniacin or nicotinic acid fibric acid derivativessuch as fenofibratecolchicinea medicine used to treat gout)

A population pharmacokinetic analysis revealed no clinically relevant differences in pharmacokinetics among CaucasianHispanicand Black or Afro-Caribbean groupsHoweverpharmacokinetic studiesincluding one conducted in the UShave demonstrated an approximate 2fold elevation in median exposureAUC and Cmaxin Asian subjects when compared with a Caucasian control group.

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