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Concomitant use of losartan and ACE-inhibitors has shown to impair renal functionThereforeconcomitant use is not recommendedsee section 4.5

Patients with primary aldosteronism generally will not respond to antihypertensive medicinal products acting through inhibition of the renin-angiotensin systemThereforethe use of losartan is not recommended.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effectsMany people using this medication do not have serious side effects.

This list is not completeOther drugs may interact with losartanincluding prescription and over-the-counter medicinesvitaminsand herbal productsNot all possible interactions are listed in this medication guide.

There is evidence that the concomitant use of ACE-inhibitorsangiotensin II receptor blockers or aliskiren increases the risk of hypotensionhyperkalaemiaand decreased renal functionincluding acute renal failureDual blockade of RAAS through the combined use of ACE-inhibitorsangiotensin II receptor blockers or aliskiren is therefore not recommendedsee sections 4.5 and 5.1

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