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Before taking baclofentell your doctor or pharmacist if you are allergic to itor if you have any other allergiesThis product may contain inactive ingredientswhich can cause allergic reactions or other problemsTalk to your pharmacist for more details.
It is mandatory that the patientall patient caregiversand the physicians responsible for the patient receive adequate information regarding the risks of this mode of treatmentAll medical personnel and caregivers should be instructed in 1the signs and symptoms of overdose2procedures to be followed in the event of overdose and 3proper home care of the pump and insertion site.
An attempt should be made to discontinue concomitant oral antispasticity medication to avoid possible overdose or adverse drug interactionseither prior to screening or following implant and initiation of chronic LIORESAL INTRATHECAL infusionReduction and discontinuation of oral anti-spasmotics should be done slowly and with careful monitoring by the physicianAbrupt reduction or discontinuation of concomitant antispastics should be avoided.
Extreme caution must be used when filling an FDA approved implantable pump equipped with an injection port that allows direct access to the intrathecal catheterDirect injection into the catheter through the catheter access port may cause a life-threatening overdose.
Considerations based on experience with oral LIORESALbaclofen USPA dose-related increase in incidence of ovarian cysts was observed in female rats treated chronically with oral LIORESALOvarian cysts have been found by palpation in about 4of the multiple sclerosis patients who were treated with oral LIORESAL for up to one yearIn most cases these cysts disappeared spontaneously while patients continued to receive the drugOvarian cysts are estimated to occur spontaneously in approximately 1to 5of the normal female population.
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