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Anemia has occurred in NSAID-treated patientsThis may be due to occult or gross blood lossfluid retentionor an incompletely described effect on erythropoiesisIf a patient treated with FELDENE has any signs or symptoms of anemiamonitor hemoglobin or hematocrit.
DiureticsNon-steroidal anti-inflammatory drugs may cause sodiumpotassium and fluid retention and may interfere with the natriuretic action of diuretic agentsThese properties should be kept in mind when treating patients with compromised cardiac function or hypertension since they may be responsible for the worsening of those conditions.
Patients who are known or suspected to be poor CYP2C9 metabolizers based on previous history/experience with other CYP2C9 substrates should be administered piroxicam with caution as they may have abnormally high plasma levels due to reduced metabolic clearancesee section 5.2
NSAIDsincluding piroxicamcan cause serious skin adverse reactions such as exfoliative dermatitisStevensJohnson SyndromeSJSand toxic epidermal necrolysisTENwhich can be fatalThese serious events may occur without warningInform patients about the signs and symptoms of serious skin reactionsand to discontinue the use of FELDENE at the first appearance of skin rash or any other sign of hypersensitivityFELDENE is contraindicated in patients with previous serious skin reactions to NSAIDssee CONTRAINDICATIONS
MifepristoneNSAIDs could interfere with mifepristone-mediated termination of pregnancy.
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