5 for men or egfr 60 possible chronic kidney disease stage 3 or greater calculated using the modification of diet in renal disease mdrd equation ; pregnancy or lactation, or intention to become pregnant in next 12 months; history of previous lung, kidney, pancreas, liver, cardiac or bone marrow transplant; history of drug or alcohol abuse within the previous 5 years, or current weekly alcohol consumption 10 units week; use of warfarin coumadin , clopidogrel plavix , dipyridamole persantine , heparin or other anticoagulants, probenecid benemid, probalan , sulfinpyrazone anturane or other uricosuric agents; subjects must agree to not use high-dose aspirin during the course of the study.
Information about Coumadin.
Many other medicines can interact with COUMADIN and affect the dose you need or increase COUMADIN side effectsDo not change or stop any of your medicines or start any new medicines before you talk to your healthcare provider.
Check with your doctor before starting any exercise or sports programYour doctor may want you to avoid activities that may cause a serious fall or other injury.
Clinical factors including ageracebody weightsexconcomitant medicationsand comorbidities Genetic factorsCYP2C9 and VKORC1 genotypessee CLINICAL PHARMACOLOGY
Consult the labeling of all concurrently used drugs to obtain further information about interactions with COUMADIN or adverse reactions pertaining to bleeding.
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47 percent per year for those taking warfarin or coumadin.
