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Report any new or worsening symptoms to your doctorsuch asmood or behavior changesdepressionanxietyor if you feel agitatedhostileirritablehyperactivementally or physicallyor have thoughts about suicide or hurting yourself.

Potential drug interactions between KEPPRA and other AEDscarbamazepinegabapentinlamotriginephenobarbitalphenytoinprimidone and valproatewere also assessed by evaluating the serum concentrations of levetiracetam and these AEDs during placebo-controlled clinical studiesThese data indicate that levetiracetam does not influence the plasma concentration of other AEDs and that these AEDs do not influence the pharmacokinetics of levetiracetam.

Howeverif levetiracetam treatment is needed during breastfeedingthe benefit/risk of the treatment should be weighed considering the importance of breastfeeding.

Pre-marketing data from clinical studies conducted in adults indicate that levetiracetam did not influence the serum concentrations of existing antiepileptic medicinal productsphenytoincarbamazepinevalproic acidphenobarbitallamotriginegabapentin and primidoneand that these antiepileptic medicinal products did not influence the pharmacokinetics of levetiracetam.

This is a summary of the European public assessment reportEPARfor KeppraIt explains how the Committee for Medicinal Products for Human UseCHMPassessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Keppra.

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