The plasma half-life of ethionamide following a 250-mg oral dose given as film-coated tablets is 1.
Information about Ethionamide.
If your symptoms or health problems do not get better or if they become worsecall your doctorDo not share your drugs with others and do not take anyone else’s drugsKeep a list of all your drugsprescriptionnatural productsvitaminsOTCwith youGive this list to your doctorTalk with the doctor before starting any new drugincluding prescription or OTCnatural productsor vitaminsSome drugs may have another patient information leafletCheck with your pharmacistIf you have any questions about ethionamideplease talk with your doctornursepharmacistor other health care providerIf you think there has been an overdosecall your poison control center or get medical care right awayBe ready to tell or show what was takenhow muchand when it happened.
Ethionamide is generally bacteriostatic at the doses that can be achieved in humansSince its action is somewhat similar to isoniazid’sand the latter appears to have AUC/MIC as the primary pharmacodynamically linked variableperhaps that also is true of ethionamide.
If you have diabetesthis product may lower your blood sugarCheck your blood sugar regularly as directed and share the results with your doctorTell your doctor right away if you have symptoms of low blood sugarsuch as sudden sweatingshakingfast heartbeathungerblurred visiondizzinessor tingling hands/feetYour doctor may need to adjust your diabetes medicationexercise programor diet.
Gastrointestinal intolerance is by far the major problem with ethionamidenausea is common and vomiting may occurHepatocellular injury is possible with ethionamide but is not commonVarious CNS effects have been reportedHypothyroidismgynecomastiaalopeciaimpotence also have been reported.
Use this medicine for the full prescribed length of timeYour symptoms may improve before the infection is completely clearedSkipping doses may also increase your risk of further infection that is resistant to antibioticsEthionamide will not treat a viral infection such as the flu or a common cold.
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the worldwide interest in the 1950s in nicotinamide isoniazid analogues for the treatment of tb led to other agents, including pyrazinamide and ethionamide, both of which are still used in some combination-treatment regimens greenwood, 2008 .
