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The CHMP harmonised the contraindication as followshypersensitivityallergyto dihydropyridine derivativesamlodipine or to any of the excipientssevere hypotensionlow blood pressureshocka steep fall in blood pressureobstruction of the outflow tract of the left ventriclea chamber in the heartand patients with heart failure following a heart attack.
CommentThe dosage should be adjusted according to patient responseIn generaltitration should proceed over 7 to 14 daysIf clinically warrantedtitration may proceed more rapidlyprovided the patient is assessed frequently.
Elevated systolic or diastolic pressure causes increased cardiovascular riskand the absolute risk increase per mmHg is greater at higher blood pressuresso that even modest reductions of severe hypertension can provide substantial benefitRelative risk reduction from blood pressure reduction is similar across populations with varying absolute riskso the absolute benefit is greater in patients who are at higher risk independent of their hypertensionfor examplepatients with diabetes or hyperlipidemiaand such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal.
Norvasc has been used safely in patients with chronic obstructive pulmonary diseasewell-compensated congestive heart failurecoronary artery diseaseperipheral vascular diseasediabetes mellitusand abnormal lipid profiles.
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norvasc savings card program eligible patients may pay as little as 0 per 30-day prescription with savings of up to 75 per fill; for additional information contact the program at 855-252-0283.
