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However, more variability was observed in some of the pharmacokinetic parameters for bupropion auc, c max , and t max and its active metabolites t in subjects with mild-to-moderate hepatic cirrhosis.

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Report any new or worsening symptoms to your doctorsuch asmood or behavior changesanxietypanic attackstrouble sleepingor if you feel impulsiveirritableagitatedhostileaggressiverestlesshyperactivementally or physicallymore depressedor have thoughts about suicide or hurting yourself.

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Bupropion is used to treat the symptoms of depression and seasonal affective disorderSADWith SADpeople have episodes of depression that occur in the fall and winter.

XL and SR tablets are intended for oral use only Inhaling crushed tablets or injecting dissolved tablets has been reported to cause seizures and/or death.

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known clinically significant potent inhibitors of cyp2d6 are antidepressants such as fluvoxamine, fluoxetine, paroxetine, sertraline, bupropion, clomipramine, and desipramine; antipsychotics such as chlorpromazine, fluphenazine, haloperidol, and thioridazine; antiarrhythmics such as quinidine or propafenone; antiretrovirals such as ritonavir; antihistamines such as diphenhydramine; antimalarials such as hydroxychloroquine or quinidine; antifungals such as terbinafine.

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