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Tolbutamide’s conversion to inactive metabolites has been shown to be catalyzed by xanthine oxidase from rat liverThe clinical significanceif anyof these observations is unknown.
ChildrenChildren should not take allopurinolexcept in cases where increased uric acid levels in the blood are associated with cancer or with Lesch-Nyhan syndromeThe safety and effectiveness of allopurinol for this age group have not been established in treatment of other conditions.
Get emergency medical help if you have any of these signs of an allergic reactionhivesdifficult breathingswelling of your facelipstongueor throat.
Hyperuricemia may be primaryas in goutor secondary to diseases such as acute and chronic leukemiapolycythemia veramultiple myelomaand psoriasisIt may occur with the use of diuretic agentsduring renal dialysisin the presence of renal damageduring starvation or reducing dietsand in the treatment of neoplastic disease where rapid resolution of tissue masses may occurAsymptomatic hyperuricemia is not an indication for treatment with Zyloprimsee INDICATIONS AND USAGE
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