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Clinical experience indicates that a 2-5decrease in total cholesterol plasma concentration and a 3-7decrease in the combined LDL CVLDL C fraction plasma concentration from pretreatment values are associated with the administration of therapeutic doses of terazosin.
Caution should be observed when terazosin is administered with other antihypertensive agentsto avoid the possibility of significant hypotensionWhen adding terazosin to a diuretic or other antihypertensive agentdosage reduction and retitration may be necessary.
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Caution should be observed when HYTRIN tablets are administered concomitantly with other antihypertensive agentsespecially the calcium channel blocker verapamilto avoid the possibility of developing significant hypotensionWhen using HYTRIN tablets and other antihypertensive agents concomitantlydosage reduction and retitration of either agent may be necessarysee PRECAUTIONSHypotension has been reported when Hytrin has been used with phosphodiesterase-5PDE-5inhibitors.
The symptoms associated with BPH are related to bladder outlet obstructionwhich is comprised of two underlying componentsa static component and a dynamic componentThe static component is a consequence of an increase in prostate sizeOver timethe prostate will continue to enlargeHoweverclinical studies have demonstrated that the size of the prostate does not correlate with the severity of BPH symptoms or the degree of urinary obstruction1 The dynamic component is a function of an increase in smooth muscle tone in the prostate and bladder neckleading to constriction of the bladder outletSmooth muscle tone is mediated by sympathetic nervous stimulation of alpha-l adrenoceptorswhich are abundant in the prostateprostatic capsule and bladder neckThe reduction in symptoms and improvement in urine flow rates following administration of terazosin is related to relaxation of smooth muscle produced by blockade of alpha-l adrenoceptors in the bladder neck and prostateBecause there are relatively few alpha-l adrenoceptors in the bladder bodyterazosin is able to reduce the bladder outlet obstruction without affecting bladder contractility.
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the main chemical ingredient of hytrin is terazosin, which works by itself or in combination with other drugs to treat high blood pressure.
