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Symptoms of overdose may include hypoglycemia symptoms as well as the following:
Your doctor will probably start you on a low dose of glipizide and gradually increase your dose if neededAfter you have taken glipizide for some timeglipizide may not control your blood sugar as well as it did at the beginning of your treatmentYour doctor may adjust the dose of your medication as needed so that the medication will work best for youBe sure to tell your doctor how you are feeling and if your blood sugar test results have been higher or lower than normal at any time during your treatment.
The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agentssome azolesand other drugs that are highly protein boundsalicylatessulfonamideschloramphenicolprobenecidcoumarinsmonoamine oxidase inhibitorsquinolones and beta adrenergic blocking agentsconverselycertain drugs tend to produce hyperglycemia and may lead to loss of controlincluding thiazides and other diureticscorticosteroidsphenothiazinesthyroid productsestrogensoral contraceptivesphenytoinnicotinic acidsympathomimeticscalcium channel blocking drugsand isoniazidwhen coadministering glipizide with such drugspatient should be observed closely for hypoglycemia or hyperglycemiawhen such drugs are withdrawnobserve patient closely for loss of control.
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