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Limited data suggest that neither metoprolol nor hydrochlorothiazide is dialyzable.

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If TOPROL-XL is used in the setting of pheochromocytomait should be given in combination with an alpha blockerand only after the alpha blocker has been initiatedAdministration of beta-blockers alone in the setting of pheochromocytoma has been associated with a paradoxical increase in blood pressure due to the attenuation of beta-mediated vasodilatation in skeletal muscle.

Tell your doctor or pharmacist if you are taking any other medicinesincluding any that you get without a prescription from your pharmacysupermarket or health food shop.

Be careful driving or operating machinery until you know how TOPROL-XL affects you.

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geriatric patients higher plasma concentrations of metoprolol can be expected in geriatric population as a result of decreased hepatic blood flow and a poorer metabolism of the drug.

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