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Latanoprost was not mutagenic in bacteriain mouse lymphomaor in mouse micronucleus testsChromosome aberrations were observed in vitro with human lymphocytesAdditional in vitro and in vivo studies on unscheduled DNA synthesis in rats were negative.

The combined use of two or more prostaglandinsor prostaglandin analogs including XALATAN is not recommendedIt has been shown that administration of these prostaglandin drug products more than once daily may decrease the IOP lowering effect or cause paradoxical elevations in IOP.

Contact lenses should be removed prior to the administration of XALATANand may be reinserted 15 minutes after administration.

Apply this medication in the affected eye(susually once daily in the eveningor as directed by your doctorDo not use this medication more frequently than prescribedusing more can decrease effectiveness.

Studies in man indicate that the peak concentration in the aqueous humour is reached about two hours after topical administrationAfter topical application in monkeyslatanoprost is distributed primarily in the anterior segmentthe conjunctivae and the eyelidsOnly minute quantities of the drug reach the posterior segment.

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