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Data collected from postmarketing use of REVIA show that most events usually occur early in the course of drug therapy and are transientIt is not always possible to distinguish these occurrences from those signs and symptoms that may result from a withdrawal syndromeEvents that have been reported include anorexiaastheniachest painfatigueheadachehot flushesmalaisechanges in blood pressureagitationdizzinesshyperkinesianauseavomitingtremorabdominal paindiarrheapalpitationsmyalgiaanxietyconfusioneuphoriahallucinationsinsomnianervousnesssomnolenceabnormal thinkingdyspnearashincreased sweatingvision abnormalitiesand idiopathic thrombocytopenic purpura.
Patients taking REVIA may not benefit from opioid containing medicinessuch as cough and cold preparationsantidiarrheal preparationsand opioid analgesicsIn an emergency situation when opioid analgesia must be administered to a patient receiving REVIAthe amount of opioid required may be greater than usualand the resulting respiratory depression may be deeper and more prolongedsee PRECAUTIONS
After opioid detoxificationpatients are likely to have reduced tolerance to opioidsAs the blockade of exogenous opioids provided by REVIA wanes and eventually dissipates completelypatients who have been treated with REVIA may respond to lower doses of opioids than previously usedjust as they would shortly after completing detoxification.
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in the russian trial as in others, more than 80 percent of patients taking the daily naltrexone pill relapsed within 6 months.
