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In controlled clinical trialsYMDD-mutant HBV was detected in subjects with on-Epivir-HBV re-appearance of HBV DNA after an initial decline below the solution-hybridization assay limitsee Microbiology12.4Subjects treated with Epivir-HBVadults and childrenwith YMDD-mutant HBV at 52 weeks showed diminished treatment responses in comparison with subjects treated with Epivir-HBV without evidence of YMDD substitutionsincluding the followinglower rates of HBeAg seroconversion and HBeAg lossno greater than placebo recipientsmore frequent return of positive HBV DNAand more frequent ALT elevationsIn the controlled trialswhen subjects developed YMDD-mutant HBVthey had a rise in HBV DNA and ALT from their own previous on-treatment levelsProgression of hepatitis Bincluding deathhas been reported in some subjects with YMDD-mutant HBVincluding subjects from the liver transplant setting and from other clinical trialsIn clinical practicemonitoring of ALT and HBV DNA levels during treatment with Epivir-HBV may aid in treatment decisions if emergence of viral mutants is suspected.
Taking Epivir HBV will not prevent you from passing HIV to other peopleDo not have unprotected sex or share razors or toothbrushesTalk with your doctor about safe ways to prevent HIV transmission during sexSharing drug or medicine needles is never safeeven for a healthy person.
Generic Name and FormulationsLamivudine 5mg/mLstrawberry-banana flavorcontains sucrose.
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combivir a fixed-dose combination tablet of lamivudine and zidovudine should not be administered concomitantly with epivir, epivir-hbv, epzicom, retrovir, or trizivir.
