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In some casesthe second malignancy developed several years after cyclophosphamide treatment had been discontinuedIn a single breast cancer trial utilizing two to four times the standard dose of cyclophosphamide in conjunction with doxorubicin a small number of cases of secondary acute myeloid leukemia occurred within two years of treatment initiationUrinary bladder malignancies generally have occurred in patients who previously had hemorrhagic cystitisIn patients treated with cyclophosphamide-containing regimens for a variety of solid tumorsisolated case reports of secondary malignancies have been publishedOne case of carcinoma of the renal pelvis was reported in a patient receiving long-term cyclophosphamide therapy for cerebral vasculitisThe possibility of cyclophosphamide-induced malignancy should be considered in any benefit-to-risk assessment for use of the drug.
Information on adverse reactions associated with the use of Cytoxancyclophosphamideis arranged according to body system affected or type of reactionThe adverse reactions are listed in order of decreasing incidenceThe most serious adverse reactions are described in the WARNINGS section.
This drug passes into breast milk and may harm a nursing infantBreast-feeding while using this drug is not recommendedConsult your doctor before breast-feeding.
Special attention to the possible development of toxicity should be exercised in patients being treated with cyclophosphamide if any of the following conditions are present.
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patients should discuss all vaccinations with their doctor because some are not advisable to get while taking cytoxan.
