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Analyses were also performed in each study to examine the effect of NEURONTIN on preventing secondarily generalized tonic-clonic seizuresPatients who experienced a secondarily generalized tonic-clonic seizure in either the baseline or in the treatment period in all three placebo-controlled studies were included in these analysesThere were several response ratio comparisons that showed a statistically significant advantage for NEURONTIN compared to placebo and favorable trends for almost all comparisons.
Antiepileptic drugs should not be abruptly discontinued because of the possibility of increasing seizure frequency.
Do not stop taking NEURONTIN without first talking to a healthcare provider.
Gabapentin is not appreciably metabolized nor does it interfere with the metabolism of commonly coadministered antiepileptic drugssee CLINICAL PHARMACOLOGY
Gabapentin did not demonstrate mutagenic or genotoxic potential in three in vitro and four in vivo assaysIt was negative in the Ames test and the in vitro HGPRT forward mutation assay in Chinese hamster lung cellsit did not produce significant increases in chromosomal aberrations in the in vitro Chinese hamster lung cell assayit was negative in the in vivo chromosomal aberration assay and in the in vivo micronucleus test in Chinese hamster bone marrowit was negative in the in vivo mouse micronucleus assayand it did not induce unscheduled DNA synthesis in hepatocytes from rats given gabapentin.
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