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There were no studies of the effects of colchicine capsules on fertilityHoweverpublished nonclinical studies have demonstrated that colchicine-induced disruption of microtubule formation affects meiosis and mitosisPublished reproductive studies with colchicine reported abnormal sperm morphology and reduced sperm counts in malesand interference with sperm penetrationsecond meiotic divisionand normal cleavage in females.
After completion of a courseanother course should not be started for at least 3 days72 hours
If a dose of colchicine capsules is missedadvise the patient to take the dose as soon as possible and then return to the normal dosing scheduleHoweverif a dose is skippedthe patient should not double the next dose.
Advise patients that many drugs or other substances may interact with colchicine capsules and some interactions could be fatalThereforepatients should report to their healthcare provider all of the current medications they are takingand check with their healthcare provider before starting any new medicationsincluding short-term medications such as antibioticsPatients should also be advised to report the use of non-prescription medication or herbal productsGrapefruit and grapefruit juice may also interact and should not be consumed during treatment with colchicine capsules.
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