In a randomized, open-label, multi-center trial study 1 , 1589 kidney transplant patients received prograf group c, n 401 , sirolimus group d, n 399 , or one of two cyclosporine csa regimens group a, n 390 and group b, n 399 in combination with mmf and corticosteroids; all patients, except those in one of the two cyclosporine groups, also received induction with daclizumab.
Information about Prograf.
Prograf is indicated for the prophylaxis of organ rejection in patients receiving allogeneic heart transplantsIt is recommended that Prograf be used concomitantly with azathioprine or mycophenolate mofetilMMFand adrenal corticosteroidssee Clinical StudiesTherapeutic drug monitoring is recommended for all patients receiving Prografsee DOSAGE AND ADMINISTRATION
Use with sirolimus is not recommended in liver and heart transplantThe safety and efficacy of Prograf with sirolimus has not been established in kidney transplantsee WARNINGS AND PRECAUTIONS
Due to the chemical instability of tacrolimus in alkaline mediaPrograf injection should not be mixed or co-infused with solutions of pH 9 or greatere.gganciclovir or acyclovir
Dosage is based on your weightmedical conditionblood test resultse.gtacrolimus trough levelsand response to therapy.
Before taking tacrolimustell your doctor or pharmacist if you are allergic to itor to other macrolide medicationssuch as sirolimusor if you have any other allergiesThis product may contain inactive ingredientswhich can cause allergic reactions or other problemsTalk to your pharmacist for more details.
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