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After completion of a courseanother course should not be started for at least 3 days72 hours
The first stage of acute colchicine toxicity typically begins within 24 hours of ingestion and includes gastrointestinal symptoms such as abdominal painnauseavomitingdiarrheaand significant fluid lossleading to volume depletionPeripheral leukocytosis may also be seenLife-threatening complications occur during the second stagewhich occurs 24 to 72 hours after drug administrationattributed to multi-organ failure and its associated consequencesDeath usually results from respiratory depression and cardiovascular collapseIf the patient survivesrecovery of multi-organ injury may be accompanied by rebound leukocytosis and alopecia starting about 1 week after the initial ingestionTreatment of colchicine overdose should begin with gastric lavage and measures to prevent shockOtherwisetreatment is symptomatic and supportiveNo specific antidote is knownColchicine is not effectively removed by hemodialysisSee Pharmacokinetics
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
Co-administration with P-gp inhibitors and/or moderate or strong CYP3A4 inhibitors will increase the exposure to colchicinewhich may lead to colchicine induced toxicity including fatalitiesIf treatment with a P-gp inhibitor or a moderate or strong CYP3A4 inhibitor is required in patients with normal renal and hepatic functiona reduction in colchicine dosage or interruption of colchicine treatment is recommendedsee section 4.5
Colchicine may be used as part of a combination therapyThis means you may need to take it with other medications.
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