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Etodolac extended-release tablets should be used with caution in patients with fluid retention or heart failure.

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Etodolac works by blocking the effect of natural substances in your bodycalled cyclo-oxygenaseCOXenzymesThese enzymes help to make other chemicals in your bodycalled prostaglandinsSome prostaglandins are produced at sites of injury or damageand cause pain and inflammationBy blocking the effect of COX enzymesfewer prostaglandins are producedwhich means pain and inflammation are eased.

Clinical trial and epidemiological data suggest that use of some NSAIDsparticularly at high doses and in long term treatmentmay be associated with an increased risk of arterial thrombotic eventsfor example myocardial infarction or strokesee section 4.4

One tablet dailyswallowed whole with a tumblerful of waterIf a lower dose is sufficientconventional Lodine capsules or tablets may be used.

Lodine can cause dizzinessdrowsinessfatigue or abnormal visionPatients need to be aware of how they react to this medicine before driving or operating machines.

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the effects of etodolac on labor and delivery in pregnant women are unknown.

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