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There have been rare reports of increased prothrombin time in patients taking coumarin anticoagulants to whom Procardia was administeredHoweverthe relationship to Procardia therapy is uncertain.
Procardialike other calcium channel blockersdecreases platelet aggregation in vitroLimited clinical studies have demonstrated a moderate but statistically significant decrease in platelet aggregation and an increase in bleeding time in some Procardia patientsThis is thought to be a function of inhibition of calcium transport across the platelet membraneNo clinical significance for these findings has been demonstrated.
Take this medication by mouthusually 3 times daily with or without food or as directed by your doctorSwallow this medication wholeDo not crushchewor break the capsule.
Procardia is a calcium ion influx inhibitorslow-channel blocker or calcium ion antagonistand inhibits the transmembrane influx of calcium ions into cardiac muscle and smooth muscleThe contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channelsProcardia selectively inhibits calcium ion influx across the cell membrane of cardiac muscle and vascular smooth muscle without changing serum calcium concentrations.
Other medications can affect the removal of nifedipine from your bodywhich may affect how nifedipine worksExamples include apalutamidecimetidineenzalutamideStJohn’s wortrifamycinssuch as rifabutinrifampindrugs used to treat seizuressuch as carbamazepinephenytoinamong others.
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