Mestinon is an antagonist to cholinesterase, the enzyme which normally destroys acetylcholine.
Information about Mestinon.
The side effects of Mestinon are most commonly related to overdosage and generally are of two varietiesmuscarinic and nicotinicAmong those in the former group are nauseavomitingdiarrheaabdominal crampsincreased peristalsisincreased salivationincreased bronchial secretionsmiosis and diaphoresisNicotinic side effects are comprised chiefly of muscle crampsfasciculation and weaknessMuscarinic side effects can usually be counteracted by atropinebut for reasons shown in the preceding section the expedient is not without dangerAs with any compound containing the bromide radicala skin rash may be seen in an occasional patientSuch reactions usually subside promptly upon discontinuance of the medication.
Mestinonpyridostigmine bromide tabletsUSPis an orally active cholinesterase inhibitorChemicallypyridostigmine bromide is 3-hydroxy-1-methylpyridinium bromide dimethylcarbamateIts structural formula is:
SMA is a genetic neurodegenerative disease that involves impairment of the neuromuscular transmissionSo Mestinonwhich facilitates the nerve signal transmission at the neuromuscular junctionNMJby inhibiting acetylcholine breakdowncould be a potential therapy for SMA.
Tell your doctor right away if you have any serious side effectsincludingnew or increased muscle cramps/weakness/twitchingslow heartbeatdizziness.
Pyridostigmine is used to improve muscle strength in patients with a certain muscle diseasemyasthenia gravisIt works by preventing the breakdown of a certain natural substanceacetylcholinein your bodyAcetylcholine is needed for normal muscle function.
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