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Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongationThis risk may increase if you use certain drugssuch as diureticswater pillsor if you have conditions such as severe sweatingdiarrheaor vomitingTalk to your doctor about using trazodone safely.
In vitro drug metabolism studies suggest that there is a potential for drug interactions when trazodone is given with CYP3A4 inhibitorsRitonavira potent CYP3A4 inhibitorincreased the C maxAUCand elimination half-lifeand decreased clearance of trazodone after administration of ritonavir twice daily for 2 daysAdverse effects including nauseahypotensionand syncope were observed when ritonavir and trazodone were co-administeredIt is likely that ketoconazoleindinavirand other CYP3A4 inhibitors such as itraconazole or nefazodone may lead to substantial increases in trazodone plasma concentrationswith the potential for adverse effectsIf trazodone is used with a potent CYP3A4 inhibitora lower dose of trazodone should be considered.
This is not a complete list of possible side effectsIf you notice other effects not listed abovecontact your doctor or pharmacist.
Do not drink alcoholTrazodone can increase the effects of alcoholwhich could be dangerous.
Chest pain or pressuretight feeling in your neck or jawsweatingpain spreading to your arm or shoulder;
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