Educate patients that wellbutrin xl contains the same active ingredient bupropion found in zyban, which is used as an aid to smoking cessation treatment, and that wellbutrin xl should not be used in combination with zyban or any other medications that contain bupropion hydrochloride such as wellbutrin sr, the sustained-release formulation, wellbutrin, the immediate-release formulation, and aplenzin, a bupropion hydrobromide formulation .
Information about Bupropion.
Assess blood pressure before initiating treatment with sustained release formulationand monitor periodically during treatmentrisk of hypertension is increased if sustained release formulation is used concomitantly with MAOIs or other drugs that increase dopaminergic or noradrenergic activityuse caution in people with cardiovascular disease.
Seizure risk is dose-relatedcan be minimized by limiting daily intake to 522 mg and gradually increasingdiscontinue permanently in people who experience seizures.
Bupropion may cause seizuresespecially in people with certain medical conditions or when using certain drugsTell your doctor about all of your medical conditions and the drugs you use.
Monoamine oxidase inhibitorsMAOIssuch as phenelzine or selegilineUsing these drugs with bupropion can result in severe high blood pressureAt least 14 days should pass between your use of an MAOI and use of bupropion.
Bupropion belongs to a class of drugs called antidepressantA class of drugs is a group of medications that work in a similar wayThese drugs are often used to treat similar conditions.
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additional events to those listed in table 4 that occurred at an incidence of at least 1 in controlled clinical trials of the immediate-release formulation of bupropion 300 to 600 mg day and that were numerically more frequent than placebo were cardiac arrhythmias 5 vs 4 , hypertension 4 vs 2 , hypotension 3 vs 2 , tachycardia 11 vs 9 , appetite increase 4 vs 2 , dyspepsia 3 vs 2 , menstrual complaints 5 vs 1 , akathisia 2 vs 1 , impaired sleep quality 4 vs 2 , sensory disturbance 4 vs 3 , confusion 8 vs 5 , decreased libido 3 vs 2 , hostility 6 vs 4 , auditory disturbance 5 vs 3 , and gustatory disturbance 3 vs 1 .
