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Upon laning that Amitiptylin is ototoxic, I bliv that it contibutd tmy poound haing loss. I hav takn this dug ov 15 yas and only cntly stoppd. Mnds tb don tmak patints awa ototoxic dugs, including nospoin, aspin, solvnts, ubbing alcohol tnam a w.
Th CYP3A4 and CYP1A2 isozyms mtabolis amitiptylin ta lss xtnt. Howv, luvoxamin (stong CYP1A2 inhibito) was shown tincas amitiptylin plasma concntations and this combination should b avoidd. Clinically lvant intactions may b xpctd with concomitant us amitiptylin and stong CYP3A4 inhibitos such as ktoconazol, itaconazol and itonavi.
Tatmnt is symptomatic and should thb continud an appopiat lngth tim. In many patints, thapy may b ndd sval yas. gula assssmnt is commndd tconim that continuation th tatmnt mains appopiat th patint.
In th psnc thanol amitiptylin plasma concntations and notiptylin concntations w incasd.
Suicidal thoughts and bhavious may alsdvlop duing aly tatmnt with antidpssants disods oth than dpssion; th sam pcautions obsvd whn tating patints with dpssion should thb ollowd whn tating patints with nusis.
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depending on individual patient response, a lower dose of amitriptyline should be considered if a strong cyp2d6 inhibitor e.
