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Before taking this medicationtell your doctor if you are using any of the following drugs:

Before using this medicationtell your doctor if you have heart or liver diseaseor a breathing disorder.

The most likely signs and symptoms to be expected with overdosage are dehydration and electrolyte imbalanceThese can be treated by established proceduresTherapy with MIDAMORamilorideshould be discontinued and the patient observed closelyThere is no specific antidoteEmesis should be induced or gastric lavage performedTreatment is symptomatic and supportiveIf hyperkalemia occursactive measures should be taken to reduce the serum potassium levels.

When amiloride HCl is administered concomitantly with an angiotensin-converting enzyme inhibitorthe risk of hyperkalemia may be increasedThereforeif concomitant use of these agents is indicated because of demonstrated hypokalemiathey should be used with caution and with frequent monitoring of serum potassiumSee WARNINGS

Electrolyte Imbalance and BUN IncreasesHyponatremia and hypochloremia may occur when MIDAMORamilorideis used with other diuretics and increases in BUN levels have been reportedThese increases usually have accompanied vigorous fluid eliminationespecially when diuretic therapy was used in seriously ill patientssuch as those who had hepatic cirrhosis with ascites and metabolic alkalosisor those with resistant edemaThereforewhen MIDAMORamilorideis given with other diuretics to such patientscareful monitoring of serum electrolytes and BUN levels is importantIn patients with pre-existing severe liver diseasehepatic encephalopathymanifested by tremorsconfusionand comaand increased jaundicehave been reported in association with diureticsincluding amiloride HCl.

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