Methotrexate is extensively protein bound and may be displaced by certain drugs such as salicylates, hypoglycaemics, diuretics, sulphonamides, diphenylhydantoins, tetracyclines, chloramphenicol and p-aminobenzoic acid, and the acidic anti-inflammatory agents, so causing a potential for increased toxicity when used concurrently.
Information about Methotrexate.
Methotrexate can cause serious or life-threatening side effectsTell your doctor if you have diarrheamouth sorescoughshortness of breathupper stomach paindark urinenumbness or tinglingmuscle weaknessconfusionseizureor skin rash that spreads and causes blistering and peeling.
Early treatment of rheumatoid arthritis with more aggressive therapy such as methotrexate helps to reduce further joint damage and to preserve joint function.
Methotrexate is sometimes taken once or twice per week and not every dayYou must use the correct doseSome people have died after taking methotrexate every day by accidentAsk your doctor or pharmacist if you have questions about your dose or how often to take it.
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special precautions to take while your child is taking methotrexate.
