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OverdoseSigns of overdose may appear suddenly or insidiouslyAcute massive overdose may present as comaLess sudden and/or less severe forms of overdose may present with signs of drowsinesslightheadednessdizzinesssomnolencerespiratory depressionseizuresrostral progression of hypotonia and loss of consciousness progressing to comaShould overdose appear likelythe patient should be taken immediately to a hospital for assessment and emptying of the pump reservoirIn cases reported to dateoverdose has generally been related to pump malfunctioninadvertent subcutaneous injectionor dosing errorSee Drug Overdose Symptoms and Treatment
Strict aseptic technique in filling is required to avoid bacterial contamination and serious infectionA period of observation appropriate to the clinical situation should follow each refill or manipulation of the drug reservoir.
Postmarketing ExperienceThe following adverse events have been reported during post-approval use of LIORESAL INTRATHECALBecause these events are reported voluntarily from a population of uncertain sizeit is not possible to reliably estimate their frequency.
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once the maximum recommended dose has been reached, if the therapeutic effect is not apparent within 6 weeks a decision whether to continue with lioresal should be taken.
