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Information about Lamisil.
If you are not sure if your medicine is one listed aboveask your doctor or pharmacist.
Seek medical treatment if you have a serious drug reaction that can affect many parts of your bodySymptoms may includeskin rashfeverswollen glandsflu-like symptomsmuscle achessevere weaknessunusual bruisingor yellowing of your skin or eyesThis reaction may occur several weeks after you began using terbinafine.
The results of a variety of in vitromutations in Ecoli and StyphimuriumDNA repair in rat hepatocytesmutagenicity in Chinese hamster fibroblastschromosome aberrationand sister chromatid exchanges in Chinese hamster lung cellsand in vivochromosome aberration in Chinese hamstersmicronucleus test in micegenotoxicity tests gave no evidence of a mutagenic or clastogenic potential.
A wide range of in vivo studies in miceratsdogsand monkeysand in vitro studies using ratmonkeyand human hepatocytes suggest that peroxisome proliferation in the liver is a rat-specific findingHoweverother effectsincluding increased liver weights and APTToccurred in dogs and monkeys at doses giving Css trough levels of the parent terbinafine 2-3x those seen in humans at the MRHDHigher doses were not tested.
There have been spontaneous reports of increase or decrease in prothrombin times in patients concomitantly taking oral terbinafine and warfarinhowevera causal relationship between Lamisil Tablets and these changes has not been established.
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