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CimetidineThe interaction between cimetidine and chronically administered verapamil has not been studiedVariable results on clearance have been obtained in acute studies of healthy volunteersclearance of verapamil was either reduced or unchanged.
Electrical activity through the AV node dependsto a significant degreeupon calcium influx through the slow channelBy decreasing the influx of calciumISOPTIN prolongs the effective refractory period within the AV node and slows AV conduction in a rate related manner.
Do not stop taking this medication without consulting your doctorSome conditions may become worse when this drug is suddenly stoppedYour dose may need to be gradually decreased.
Before using this medicationtell your doctor or pharmacist your medical historyespecially ofcertain types of heart rhythm problemssuch as secondor third-degree atrioventricular blocksick sinus syndrome unless you have a pacemakerWolff-Parkinson-White syndromeLown-Ganong-Levine syndromeheart failurecertain muscle/nerve disordersmuscular dystrophymyasthenia gravisliver diseasekidney disease.
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