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A small clinical study has indicated that standard therapeutic doses of Imuran do not deleteriously affect the response to polyvalent pneumococcal vaccineas assessed on the basis of mean anti-capsular specific antibody concentration.

There is limited experience of the administration of Imuran to elderly patientsAlthough the available data do not provide evidence that the incidence of side effects among elderly patients is higher than that among other patients treated with Imuranit is recommended that the dosages used should be at the lower end of the range.

Symptoms of an allergic reaction usually happen within the first few weeks of treatmentThey include:

Leucopenia and/or thrombocytopenia have been reported in a proportion of neonates whose mothers took azathioprine throughout their pregnanciesExtra care in haematological monitoring is advised during pregnancy.

Signs of an allergic reactionlike rashhivesitchingredswollenblisteredor peeling skin with or without feverwheezingtightness in the chest or throattrouble breathingswallowingor talkingunusual hoarsenessor swelling of the mouthfacelipstongueor throatSigns of infection like feverchillsvery bad sore throatear or sinus paincoughmore sputum or change in color of sputumpain with passing urinemouth soresor wound that will not healSigns of bleeding like throwing up blood or throw up that looks like coffee groundscoughing up bloodblood in the urineblackredor tarry stoolsbleeding from the gumsvaginal bleeding that is not normalbruises without a reason or that get biggeror any bleeding that is very bad or that you cannot stopSigns of liver problems like dark urinefeeling tirednot hungryupset stomach or stomach painlight-colored stoolsthrowing upor yellow skin or eyesSigns of a pancreas problempancreatitislike very bad stomach painvery bad back painor very bad upset stomach or throwing upChest pain or pressureVery upset stomach or throwing upFeeling very tired or weakVery bad dizziness or passing outLoose stoolsdiarrheaMuscle pain or weaknessNight sweatsA big weight lossFever that does not go awayChange in color or size of a moleA skin lump or growthA very bad brain problem called progressive multifocal leukoencephalopathyPMLhas happened with Imuranazathioprine tabletsIt may cause disability or can be deadlyTell your doctor right away if you have signs like confusionmemory problemslow mooddepressionchange in the way you actchange in strength on 1 side is greater than the othertrouble speaking or thinkingchange in balanceor change in eyesight.

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