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CholesterolThis medication may increase cholesterol and triglyceride levelsYour doctor may monitor these levels while you are taking this medicationIf you have high cholesterol or triglyceride levelsdiscuss with your doctor how this medication may affect your medical conditionhow your medical condition may affect the dosing and effectiveness of this medicationand whether any special monitoring is needed.

Suicidal or agitated behaviourPeople taking antidepressants such as desvenlafaxine may feel agitatedrestlessanxiousaggressiveemotionaltrouble sleepingand feeling not like themselvesor they may want to hurt themselves or othersThese symptoms may occur within the first few weeks of starting this medicationIf you notice any changes in moodbehavioursthoughtsor feelings in yourself or someone who is taking this medicationcontact a doctor immediatelyYour doctor will monitor you closely for behaviour changesespecially at start of treatment or when your dose is increased or decreased.

Although these symptoms usually go away without treatmenttell your doctor if you experience any of these symptomsWhen this medication is stoppedit should be stopped gradually as directed by your doctor.

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All SNRIsincluding desvenlafaxineshould not be taken with any of the monoamine oxidase inhibitorMAOIclass of antidepressantsfor exampleisocarboxazidMarplanphenelzineNardiltranylcypromineParnateselegilineEldepryland procarbazineMatulaneor other drugs that inhibit monoamine oxidasefor examplelinezolidZyvoxSuch combinations may lead to confusionhigh blood pressuretremorhyperactivitycomaand deathDesvenlafaxine should not be administered within 14 days after stopping MAOIs and MAOIs should not be administered within 7 days of stopping desvenlafaxine.

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