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Pharmacokinetics of LIORESAL INTRATHECALThe pharmacokinetics of CSF clearance of LIORESAL INTRATHECAL calculated from intrathecal bolus or continuous infusion studies approximates CSF turnoversuggesting elimination is by bulk-flow removal of CSF.
Symptoms of LIORESAL INTRATHECAL OverdoseDrowsinesslightheadednessdizzinesssomnolencerespiratory depressionhypothermiaseizuresrostral progression of hypotonia and loss of consciousness progressing to coma of up to 72 hrdurationIn most cases reportedcoma was reversible without sequelae after drug was discontinuedSymptoms of LIORESAL INTRATHECAL overdose were reported in a sensitive adult patient after receiving a 25 mcg intrathecal bolus.
Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relieverssuch as codeinehydrocodonealcoholmarijuanadrugs for sleep or anxietysuch as alprazolamlorazepamzolpidemother muscle relaxantssuch as carisoprodolcyclobenzaprineor antihistaminessuch as cetirizinediphenhydramine
Seizures have been reported during overdose and with withdrawal from LIORESAL INTRATHECAL as well as in patients maintained on therapeutic doses of LIORESAL INTRATHECAL.
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