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Avodat (dutastid) pvnts th convsion tstoston tdihydotstoston (DHT) in th body. DHT is involvd in th dvlopmnt bnign postatic hypplasia (BPH).
Th ollowing tabl shows advs actions om contolld clinical tials and post-makting xpinc. Th listd advs vnts om clinical tials a invstigato-judgd dug-latd vnts (with incidnc mthan qual t1%) potd with a high incidnc in patints tatd with dutastid compad with placbduing th ist ya tatmnt. Advs vnts om post-makting xpinc w idntiid om spontanous post-makting pots; thth tu incidnc is not known:
Dutastid is a comptitiv and spciic inhibitboth typ 1 and typ 2 5 alpha-ductas isonzyms, with which it oms a stabl nzym complx. Dissociation om this complx has bn valuatd und in vitand in vivconditions and is xtmly slow. Dutastid dos not bind tth human andogn cpto.
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